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Nephrol Dial Transplant (2001) 16: 2135-2137
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Oxidative stress in chronic renal failure

Jan Galle

Department of Medicine, Division of Nephrology, Julius-Maximilians Universität, Würzburg, Germany

Keywords: oxidative stress; chronic renal failure

Introduction

Oxidative stress defines an imbalance between formation of reactive oxygen species (ROS) and antioxidative defence mechanisms. In view of the profound biological effects of ROS, in recent years numerous clinical and experimental studies focused on detection of signs of oxidative stress in renal patients. There is good evidence indicating that uraemia in general is associated with enhanced oxidative stress [1,2], and treatment of uraemic patients with haemodialysis or peritoneal dialysis has been suggested to particularly contribute to oxidative stress and reduced antioxidant levels in these patients [3,4]. The latter may result from haemodialysis membrane-induced activation of macrophages on the surface of dialysis membranes during the dialysis session. Loss or deficiency of antioxidant activity (e.g. vitamin E deficiency) could also . . . [Full Text of this Article]

What generates oxidative stress?

Biological effects of oxidative stress

Antioxidant studies in uraemia

Conclusion

Editor's note

Notes

References


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