Nephrol Dial Transplant (2001) 16: 1971-1974
© 2001 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
The modality of dialysis treatment: does it influence the response to erythropoietin treatment?
Department of Nephrology and Dialysis, Ospedale A. Manzoni, Lecco, Italy
Keywords: anaemia; haemodialysis; membrane; convective treatments; dialysis dose; on-line treatments
Introduction
Over the last decade, the availability of recombinant uman erythropoietin (rh-Epo) has led to the almost complete disappearance of the severe anaemia of end-stage renal disease (ESRD). However, despite an increase in the use and average dose of rh-Epo, a substantial percentage of patients do not achieve a haematocrit level of more than 30% [1,2]. Although iron deficiency is probably the main factor affecting the response to rh-Epo in most patients, occult blood loss, infection, inflammation, and dialysis adequacy are also important. Given that rh-Epo resistance is a clinically and economically relevant problem, it is important to understand to what extent the mode and/or the dose of dialysis can influence anaemia and the response to rh-Epo.
Dialysis dose and frequency
Adequate dialysis can contribute to correction of anaemia by removing hypothetical small, and possibly also medium/large molecules, that potentially inhibit erythropoiesis. However, the role of dialysis dose per se on
Membranes and convective treatments
On-line treatments
Extracorporeal circuit
Conclusions
Notes
References
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