Nephrol Dial Transplant (2001) 16: 12-14
© 2001 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Recent issues concerning renal transplantation in systemic lupus erythematosus patients
Service de Néphrologie, Hôpital Saint Louis, Paris
Introduction
Renal transplantation among patients with end-stage renal disease (ESRD) caused by lupus nephritis has become an accepted alternative for long-term treatment. However, the outcome of renal transplantation in patients with systemic lupus erythematosus (SLE) is still controversial. Infection, recurrent disease, both acute and chronic rejection, and thrombosis may play a role in early graft loss. New findings for graft and patient outcome, immunological markers and immunosuppressive treatment have recently emerged. We discuss these different aspects here, with the exception of the clinical consequences of the presence of anti-endothelial cell antibodies.
Outcome analysis
An initial report that early graft survival in SLE patients was comparable to that of patients with other causes of ESRD has been confirmed by subsequent studies [1,2]. However, several of these studies were conducted in single centres with small numbers of patients. Furthermore, in these
Specific risk factors for patients with lupus nephritis
Immunological failure
Disease activity and recurrent nephritis
Thrombotic complications
Immunosuppressive treatment
Conclusion
Notes
References
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