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Nephrol Dial Transplant (2000) 15: 1278-1280
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Anaemia correction—does the mode of dialysis matter?

Editor's note See also Original Article by F. Locatelli et al. this issue, pp. 1399–1409

Kai-Uwe Eckardt

Department of Nephrology and Medical Intensive Care, Charité, Campus Virchow-Klinikum, Humboldt University, Berlin, Germany

Introduction

The enormous success of treating renal anaemia with recombinant human erythropoietin (rhEpo) during the last 15 years easily lets one forget that the discussion about the pathogenesis of renal anaemia was dominated for decades by the question whether it is primarily due to relative Epo deficiency or uraemic inhibition of erythropoiesis. Although it has so far not been possible to identify or isolate a substance retained in uraemia with a suppressive action directed specifically against red cell production, dialysis therapy can improve the effect of both residual endogenous and exogenous rhEpo. To which extent mode and/or dose of dialysis influence Epo efficacy is yet poorly understood. In this issue Locatelli et al. report the results of a prospective multicentre trial that provides some new evidence related to this question and the potential role of uraemic inhibitors of red cell production [1].

Uraemic toxins as inhibitors of erythropoiesis?

Plasma Epo levels in patients with . . . [Full Text of this Article]

Effects of dialysis in patients not treated with rhEpo

Effects of dialysis on the responsiveness to rhEpo

Conclusions

Notes

References


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