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Nephrol Dial Transplant (2000) 15: 1120-1123
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Peritoneal solute transport—we know it is important, but what is it?

Simon J. Davies

Department of Nephrology, North Staffordshire Hospital, Stoke-on-Trent and School of Postgraduate Medicine, Keele University, UK

The problem

The rate at which small molecules cross the peritoneal membrane is now established as one of the more important characteristics of patients treated by peritoneal dialysis. A number of prospective studies have demonstrated that high solute transport is associated with less satisfactory clinical outcome, including increased technical failure and reduced patient survival [1–7]. This prediction of outcome is independent of other established factors, such as residual renal function, co-morbidity (including diabetic status), body size and plasma albumin. The mechanism of this influence is probably multifactorial, although it has been known for some time that high solute transport is a common causative factor in ultrafiltration failure. This is due to the rapid rate of glucose absorption resulting in the loss of osmotic gradient early in the dialysis cycle [8,9]. Furthermore, solute transport is the one characteristic of peritoneal membrane function that has been . . . [Full Text of this Article]

Measuring solute transport

Describing solute transport

Peritoneal surface area in contact with fluid

Diffusive mass transport through the capillary wall

Diffusive transport through the interstitium

Conclusion

Acknowledgments

Notes

References


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