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Nephrol Dial Transplant (2000) 15: 1115-1117
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Leptin and blood pressure—is there a link?

Peter Stenvinkel

Division of Renal Medicine, Department of Clinical Science, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden

Introduction

It is well recognized that an increased body weight is often associated with metabolic disorders (hyperinsulinaemia and glucose intolerance), as well as increased blood pressure. Indeed, obesity activates both the sympathetic nervous and renin–angiotensin systems and causes insulin resistance and hyperinsulinaemia, all of which have been thought to raise blood pressure. The association between obesity and hypertension suggests that the adipose mass may serve as an important tissue in the regulation of blood pressure although the mechanism(s) underlying this are not yet evident. Recently it has become evident that adipocytes may function not only as energy storage depots but also as a rich source of metabolically active substances including free fatty acids, tumour necrosis factor-alpha, angiotensinogen (AGT), prostaglandins, oestrogen, and the ob gene product, leptin. Obesity and hyperinsulinism are major stimulators of leptin production, and this production is strongly and positively correlated with body fat mass [1]. There . . . [Full Text of this Article]

Is hypertension associated with hyperleptinaemia?

Leptin and insulin affect tubular sodium handling

Does leptin affect the renin–angiotensin system?

Leptin causes sympathico-activation

Summary and perspectives

Acknowledgments

Notes

References


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