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Nephrol Dial Transplant (2000) 15: 1109-1111
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

The emerging role of parathyroid hormone-related protein as a renal regulating factor

Pedro Esbrit and Jesús Egido

Bone and Mineral Metabolism Laboratory and Renal Research Laboratory, Fundación Jiménez Díaz and Universidad Autónoma, Madrid, Spain

Introduction

Parathyroid hormone (PTH)-related protein (PTHrP) was initially isolated from tumours associated with humoural hypercalcaemia of malignancy [1]. Both PTH and PTHrP share homology in their N-terminal region, and bind to the type 1 PTH/PTHrP receptor (PTHR), first cloned in osteoblasts and renal tubular cells, activating both adenylate cyclase and phospholipase C/protein kinase C [2]. However, while PTH is a regulator of mineral homeostasis, acting mainly on bone and kidney, PTHrP is now known to be widely expressed in non-malignant foetal and adult tissues [3]. Furthermore, PTHrP post-translational processing generates various fragments, including the PTH-like region and other mid- and C-terminal domains lacking PTH homology [4,5]. These fragments, interacting with specific receptors, appear to act as autocrine/paracrine regulators of cell growth and/or differentiation, at least in some tissues [1,3]. Although knowledge of the physiological role of . . . [Full Text of this Article]

PTHrP and its receptors in renal tissue

PTHrP and renal regeneration after acute renal failure

PTHrP and renal disease progression

Future perspectives

Notes

References


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