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Nephrol Dial Transplant (2000) 15: 938-940
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Renal effects of smoking: potential mechanisms and perspectives

Jean-Michel Halimi and Albert Mimran

Department of Medicine and Hypertension, Montpellier University Hospital, Montpellier, France

Introduction

It was recently suggested that smoking, in addition to its well-known cardiovascular consequences, could accelerate the progression of renal diseases [1]. However, our understanding of the acute effects and long-term influence of smoking on renal haemodynamics and albuminuria is poor, and many questions remain unanswered.

Smoking and progression of renal diseases

Increasing evidence suggests that chronic smoking adversely influences the prognosis of nephropathies [1]: smoking increases the risk of microalbuminuria and accelerates the rate of progression from microalbuminuria to proteinuria and subsequent renal failure in type 1 diabetes mellitus [1,2]. The prevalence of micro-and macro-albuminuria was higher in smokers than in non-smokers with type 2 diabetes mellitus in a population-based cohort [3]. Regarding non-diabetic nephropathies, among 270 patients with polycystic kidney disease, proteinuria was more frequent in smokers than non-smokers [4]. In addition, the median time to end-stage renal disease . . . [Full Text of this Article]

Effects of chronic smoking on renal haemodynamics and urinary albumin excretion in subjects without overt nephropathy

Acute renal effects of smoking or nicotine

Potential mechanisms

Perspectives

Notes

References


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