Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Scherberich, J. E.
Right arrow Articles by Nockher, W. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scherberich, J. E.
Right arrow Articles by Nockher, W. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2000) 15: 574-578
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Blood monocyte phenotypes and soluble endotoxin receptor CD14 in systemic inflammatory diseases and patients with chronic renal failure

Juergen E. Scherberich and Wolfgang A. Nockher1

2nd Medical Department, Hospital München-Harlaching, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität, and 1 Institute of Clinical Chemistry, Krankenhaus München-Bagenhausen, München, Germany

Introduction

Patients with end-stage renal failure undergoing chronic renal replacement therapy reveal several signs of an impaired humoral and cellular immune response [1,2]. As a consequence patients are more susceptible to bacterial infections, exhibit defective phagocytosis, altered B-/T-cell and disturbed killer cell activity, low response rate to hepatitis B vaccine, and increased risk for cancer. On the other hand, secondary immunodeficiency in chronic uraemia is masked by dialysis-related blood-membrane interactions which show chronic signs of complement and monocyte activation. In addition, changes in proinflammatory cytokine synthesis and secretion (IL1, IL6, TNF-{alpha}) and rise in acute phase reactants revealing inadequate ‘immunostimulation’ apparently contribute to progressive atherosclerotic lesions and increased cardiovascular events [3,4].

Monocytes are closely involved in antigen presentation, T- and B-cell cooperation and secretion of various monokines, and play a pivotal role not only as targets in biocompatibility but are also responsible . . . [Full Text of this Article]

CD14, a major monocyte receptor antigen

Soluble CD14 (sCD14)

CD14+/CD16+ monocytes: the proinflammatory subset

Monocyte phenotypes in patients undergoing intermittent haemodialysis (HD)

Peritoneal dialysis

Activated monocytes and drug response

CD14 and apoptosis

Monocytes/macrophages and progressive renal disease:

Notes

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
Z. Zhao, R. Fleming, B. McCloud, and M. S. Klempner
CD14 Mediates Cross Talk between Mononuclear Cells and Fibroblasts for Upregulation of Matrix Metalloproteinase 9 by Borrelia burgdorferi
Infect. Immun., June 1, 2007; 75(6): 3062 - 3069.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. Jofre, P. Rodriguez-Benitez, J. M. Lopez-Gomez, and R. Perez-Garcia
Inflammatory Syndrome in Patients on Hemodialysis
J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S274 - S280.
[Abstract] [Full Text] [PDF]