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Nephrol Dial Transplant (2000) 15: 568-571
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Great strides in the understanding of renal magnesium and calcium reabsorption

Editor's note See also Original Article by Benigno et al. in this issue.

Leo Monnens, Patrick Starremans and René Bindels

Department of Pediatrics and Cell Physiology, University of Nijmegen, Nijmegen, The Netherlands

Introduction

In this issue Benigno et al. report their personal experience and review the literature about a rare autosomal recessive disorder called hypomagnesaemia-hypercalciuria-nephrocalcinosis [1]. Elucidation of the genetic defect in this disorder identified for the first time an essential component for the paracellular transport of magnesium and calcium in the thick ascending limb (TAL) of the loop of Henle [2] and increases substantially the understanding of the transport of these cations in this part of the nephron.

This editorial comment will be divided in three parts: mechanism of magnesium and calcium transport in TAL and distal convoluted tubule (DCT); comments about the clinical symptoms of the syndrome hypomagnesaemia-hypercalciuria-nephrocalcinosis; and finally proposals for treatment.

Transport of magnesium and calcium in TAL and DCT

In Table 1Go the . . . [Full Text of this Article]

Symptoms of patients with hypomagnesaemia-hypercalciuria-nephrocalcinosis

Causes of hereditary hypomagnesaemia due to renal magnesium loss

Proposal for treatment

Notes

References


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