Nephrol Dial Transplant (2000) 15: 296-299
© 2000 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Connective tissue growth factor: just another factor in renal fibrosis?
1 Departments of Pathology and 3 Vascular Medicine, UMC Utrecht and 2 Department of Pathology, AMC Amsterdam, The Netherlands and 4 Department of Nephrology, Chubu Rousai Hospital, Nagoya, Japan
Correspondence and offprint requests to: R. Goldschmeding, Dept of Pathology H04.312, Academic Hospital Utrecht, PO BOX 85500, 3508 GA Utrecht,The Netherlands. E-mail: r.goldschmeding@lab.azu.nl
Introduction
Connective tissue growth factor (CTGF) is a novel growth factor, that occurs in a broad range of species, including man, pig, rat, mouse, cow, newt and frog. Its amino acid sequence is over 90% identical among mammals. In their quest for the genes involved in development of atherosclerosis and diabetic nephropathy, differential cloning strategies applied by Oemar et al. [1], Mason et al. [2] and Murphy et al. [3] independently revealed strong overexpression of this growth factor in atherosclerotic aorta, and in mesangial cells after prolonged culture in high concentrations of glucose, respectively. Previously, CTGF had been cloned from HUVEC by Bradham et al. Its mouse ortholog (fisp-12) had been identified in serum-stimulated NIH3T3 cells in 1988 by Almendra et al. (reviewed in [4]).
Growth factors in renal fibrosis
With respect to the kidney, CTGF represents the latest addition to the list of growth factors that might
CTGF-expression in renal disease
Regulation of (renal) CTGF expression
Biological effects of CTGF
Mechanism of CTGF action
CTGF levels in blood and body fluids
Conclusion
References
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