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Nephrol Dial Transplant (2000) 15: 293-295
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Adrenomedullin as a renal regulator peptide

Michihisa Jougasaki and John C. Burnett, Jr

Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA

Correspondence and offprint requests to: Michihisa Jougasaki, MD, PhD, Cardiorenal Research Laboratory, Mayo Clinic and Foundation, 915 Guggenheim, 200 First Street, SW Rochester, MN 55905, USA.

Keywords: adrenomedullin; hormone; peptide

Introduction

In 1993, Kitamura et al. discovered a novel hypotensive factor by means of monitoring the ability of extracted fractions of human pheochromocytoma to increase platelet cyclic adenosine 3',5'-monophosphate (cAMP) [1]. This factor is named adrenomedullin (ADM), as it is abundant in normal adrenal medulla as well as in pheochromocytoma. ADM is a 52-amino acid peptide with a ring structure and C-terminal amidation. ADM mediates vasodilating properties through cAMP and nitric oxide (NO). ADM immunoreactivity and gene expressions are widely distributed in mammalian organs, including the kidney [2,3]. ADM is present in human plasma and urine, and urinary levels are higher than plasma levels, indicating that the kidney may be one of the major organs for ADM production [4]. In addition to the vasodilating effect, ADM has diuretic and natriuretic . . . [Full Text of this Article]

Structure and molecular biology of ADM

Distribution and synthesis of ADM in the kidney

ADM receptor in the kidney

Renal physiology

Actions on the renal vessels
Natriuretic actions
Mesangial cell proliferation
Renin release
Clinical implications in renal diseases

ProADM N-terminal 20 peptide (PAMP)

Conclusion

References


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