Nephrol Dial Transplant (2000) 15: 1729-1731
© 2000 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Transdifferentiation comes of age
Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Robert-Koch-Str. 40, D-37075 Göttingen, Germany
Introduction
Five years ago we wrote an editorial in this journal about the possible transdifferentiation of tubular epithelial cells to fibroblasts [1]. We had just cloned a fibroblast specific protein (FSP)-1 in murine kidney fibroblasts and had described that de novo expression of this protein could be detected in selected tubular epithelial cells during late stages of renal fibrogenesis, indicating possible epithelial–mesenchymal transformation (EMT) or transdifferentiation [2]. After this passage of time, we would like to readdress the issue of transdifferentiation and the scientific evidence collected in the meantime supporting its existence.
As was pointed out in that first editorial, transdifferentiation is defined as the loss of one phenotype and the acquisition of a new one. Transdifferentiation is a physiological process during development but has also been described in a number of adult organs including the liver, the thyroid and the mammary glands (reviewed in [3
In vivo evidence of tubular epithelial–mesenchymal transdifferentiation
Effects of matrix components and cytokines on transdifferentiation
Tubular epithelial transdifferentiation and proliferation
Acknowledgments
Notes
References
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Niedermeier, B. Reich, M. R. Gomez, A. Denzel, K. Schmidbauer, N. Gobel, Y. Talke, F. Schweda, and M. Mack CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes PNAS, October 20, 2009; 106(42): 17892 - 17897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Dudas, R. L. Argentieri, and F. X. Farrell BMP-7 fails to attenuate TGF-{beta}1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells Nephrol. Dial. Transplant., May 1, 2009; 24(5): 1406 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zeng, Y. Yao, M. Han, X. Zhao, X.-C. Liu, J. Wei, Y. Luo, J. Zhang, J. Zhou, S. Wang, et al. Biliverdin Reductase Mediates Hypoxia-Induced EMT via PI3-Kinase and Akt J. Am. Soc. Nephrol., February 1, 2008; 19(2): 380 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. El Chaar, J. Chen, S. V. Seshan, S. Jha, I. Richardson, S. R. Ledbetter, E. D. Vaughan Jr, D. P. Poppas, and D. Felsen Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral obstruction Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1291 - F1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. McMorrow, M. M. Gaffney, C. Slattery, E. Campbell, and M. P. Ryan Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells Nephrol. Dial. Transplant., October 1, 2005; 20(10): 2215 - 2225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Slattery, E. Campbell, T. McMorrow, and M. P. Ryan Cyclosporine A-Induced Renal Fibrosis: A Role for Epithelial-Mesenchymal Transition Am. J. Pathol., August 1, 2005; 167(2): 395 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Sadlier, S. B. Connolly, N. E. Kieran, S. Roxburgh, D. P. Brazil, L. Kairaitis, Y. Wang, D. C. H. Harris, P. Doran, and H. R. Brady Sequential Extracellular Matrix-focused and Baited-global Cluster Analysis of Serial Transcriptomic Profiles Identifies Candidate Modulators of Renal Tubulointerstitial Fibrosis in Murine Adriamycin-induced Nephropathy J. Biol. Chem., July 9, 2004; 279(28): 29670 - 29680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu Epithelial to Mesenchymal Transition in Renal Fibrogenesis: Pathologic Significance, Molecular Mechanism, and Therapeutic Intervention J. Am. Soc. Nephrol., January 1, 2004; 15(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Poulsom, M. R. Alison, T. Cook, R. Jeffery, E. Ryan, S. J. Forbes, T. Hunt, S. Wyles, and N. A. Wright Bone Marrow Stem Cells Contribute to Healing of the Kidney J. Am. Soc. Nephrol., June 1, 2003; 14(90001): S48 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zeisberg, Y. Maeshima, B. Mosterman, and R. Kalluri Renal Fibrosis : Extracellular Matrix Microenvironment Regulates Migratory Behavior of Activated Tubular Epithelial Cells Am. J. Pathol., June 1, 2002; 160(6): 2001 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zeisberg, G. Bonner, Y. Maeshima, P. Colorado, G. A. Muller, F. Strutz, and R. Kalluri Renal Fibrosis : Collagen Composition and Assembly Regulates Epithelial-Mesenchymal Transdifferentiation Am. J. Pathol., October 1, 2001; 159(4): 1313 - 1321. [Abstract] [Full Text]
|
|