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Nephrol Dial Transplant (2000) 15: 1-2
© 2000 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Polycystin-1 interacts with E-cadherin and the catenins—clues to the pathogenesis of cyst formation in ADPKD?
Department of Medicine, Division of Nephrology, Columbia University, New York, USA
Correspondence and offprint requests to: Janet van Adelsberg, Assistant Professor of Medicine, Columbia University, 630 W168th St, Box 84, P&S 10-501, New York, NY 10032, USA.
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in several genes. Two of these genes, PKD1 and PKD2, have been cloned and sequenced. PKD1 codes for an integral membrane protein, polycystin-1, with a large extracellular amino terminal domain and a carboxyl terminal domain that spans the
E-cadherin complexes contain ß catenin and determine cell polarity
ß Catenin degradation is regulated by the APC complex
ß Catenin binds to transcription factors
Polycystin-1 interacts with ß catenin
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