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Nephrol Dial Transplant (1999) 14: 1846-1849
© 1999 European Renal Association-European Dialysis and Transplant Association

Invited Comment

Identification of non-diabetic glomerular disease in renal biopsies from diabetics—a dilemma

Steen Olsen

Institute of Pathology, Herlev Hospital, Copenhagen, Denmark

Correspondence and offprint requests to: Professor Steen Olsen, Jaegersborg Alle 163, DK-2820 Gentofte, Denmark.

Diabetic nephropathy is one of the most frequent and clinically important complications to diabetes mellitus (DM), affecting approximately 40% of patients who have had diabetes for more than 20 years and contributing to a substantial part of patients entering into end-stage renal failure programmes. Our knowledge of the clinical development and morphological basis for diabetic renal disease has augmented tremendously during the last half century [1,2] and during the last decade we have been able to understand at least some elements of its pathogenesis. Nephropathy in a patient suffering from DM may, however, not be related directly to the diabetic disease but may be a complicating renal disease, not due to the diabetic metabolic abnormality. The situation is further complicated since logically both lesions may be present in the same patient. While it was formerly held that non-diabetic renal disease was of minor importance in DM, . . . [Full Text of this Article]

Glomerular lesions of diabetic nephropathy

Glomerulopathy not related to the diabetic disease

Glomerulonephritis (GN)
Mesangial proliferative GN
Minimal change nephropathy
Other glomerular diseases
Conclusion

References


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