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Nephrol Dial Transplant (1999) 14: 2795-2797
© 1999 European Renal Association-European Dialysis and Transplant Association


Editorial Comments

Ischaemic nephropathy—is the diagnosis excluded by heavy proteinuria?

A. David Makanjuola and John E. Scoble

Department of Nephrology, Guy's Hospital, London

Correspondence and offprint requests to: A. David Makanjuola, Department of Nephrology and Transplantation, Guy's Hospital, London SE1 9RT, UK.

Bright's observations in 1836 [1] highlighted the link between proteinuria and renal disease. More recently, ischaemic renal disease was described by Jacobson [2] as `a clinically significant reduction in glomerular filtration rate in patients with haemodynamically significant obstruction to renal blood flow in the renal artery of a solitary kidney or in both renal arteries if both kidneys are present'. As a means of differentiating ischaemic renal disease from other glomerular diseases, Jacobson used the 24-h protein excretion rate as a discriminatory clinical feature. He stated that ischaemic renal disease would produce 24-h protein excretion rates of less than 1 g.

Atherosclerotic renal disease

Atherosclerotic renal disease is the major cause of renal artery stenosis in . . . [Full Text of this Article]

Heavy proteinuria—potential aetiologies

The histological lesions

The heterogeneity of atherosclerotic renovascular disease

Conclusion

References


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