Nephrol Dial Transplant (1999) 14: 2795-2797
© 1999 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Ischaemic nephropathyis the diagnosis excluded by heavy proteinuria?
Department of Nephrology, Guy's Hospital, London
Correspondence and offprint requests to: A. David Makanjuola, Department of Nephrology and Transplantation, Guy's Hospital, London SE1 9RT, UK.
Bright's observations in 1836 [1] highlighted the link between proteinuria and renal disease. More recently, ischaemic renal disease was described by Jacobson [2] as `a clinically significant reduction in glomerular filtration rate in patients with haemodynamically significant obstruction to renal blood flow in the renal artery of a solitary kidney or in both renal arteries if both kidneys are present'. As a means of differentiating ischaemic renal disease from other glomerular diseases, Jacobson used the 24-h protein excretion rate as a discriminatory clinical feature. He stated that ischaemic renal disease would produce 24-h protein excretion rates of less than 1 g.
Atherosclerotic renal disease
Atherosclerotic renal disease is the major cause of renal artery stenosis in
Heavy proteinuriapotential aetiologies
The histological lesions
The heterogeneity of atherosclerotic renovascular disease
Conclusion
References