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Nephrol Dial Transplant (1999) 14: 2293-2296
© 1999 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Hypercoagulable state and graft rejection—is there a link?

Stefan Heidenreich1, Ulricke Nowak-Göttl2 and Christian August3

1 Departments of Medicine, 2 Pediatrics and 3 Pathology, University of Münster, Münster, Germany

Correspondence and offprint requests to: Stefan Heidenreich, MD, Department of Medicine D, University Münster Medical School, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany.

Keywords: acute rejection; coagulation; haemostasis; thrombophilia; transplant

Introduction

Although renal allografting has become a standard procedure in transplant medicine, 10–20% of kidney grafts are lost during the first year. Acute rejection episodes are the most common cause of early transplant failure, but early graft loss due to venous or arterial thrombosis is also a well-known complication with an incidence of 1–5% [1]. More drastically, in paediatric renal transplantation vascular thrombosis is still a major issue accounting for about 12% of failed transplants and 20% of failed repeat transplants [2]. Since genetic prothrombotic risk factors have been shown to play a major role in the occurrence of various thromboembolic diseases, the relevance of hypercoagulable states in the setting of organ transplantation has attracted attention as well.

The first patient with inherited thrombophilia caused by antithrombin (AT) deficiency was described in 1965. In the 1980s, knowledge about thrombotic disorders was extended by the identification of prothrombotic . . . [Full Text of this Article]

Prothrombotic defects in chronic renal failure

Thrombophilia as a consequence of immunosuppression or virus infection

Renal transplant loss and rejection—links to prothrombotic risk factors

Conclusions and perspectives

References


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Home page
 J. Am. Soc. Nephrol.Home page
S. Heidenreich, R. Junker, H. Wolters, D. Lang, S. Hessing, G. Nitsche, and U. Nowak-Gottl
Outcome of Kidney Transplantation in Patients with Inherited Thrombophilia: Data of a Prospective Study
J. Am. Soc. Nephrol., January 1, 2003; 14(1): 234 - 239.
[Abstract] [Full Text] [PDF]