Nephrol Dial Transplant (1999) 14: 2271-2278
© 1999 European Renal Association-European Dialysis and Transplant Association
Tony Raine Memorial Lecture
Hypertensive nephrosclerosis: pathogenesis and prevalence
Essential hypertension is an important cause of end-stage renal disease
Department of Internal Medicine, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
Correspondence and offprint requests to: Robert G. Luke, MD, Chairman, Department of Internal Medicine, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267-0557, USA.
On October 14, 1995, Professor A. Raine (St Bartholomew's Hospital, London) died at the young age of 46 years. He was a fascinating man who combined a rigorous scientific approach with clinical acumen. He excelled in the fields of hypertension research and nephrological research. He was an inspiring investigator whose untimely death is mourned by many colleagues in European nephrology.
NDT commemorates the outstanding contributions of our former subject editor in the field of hypertension by a contribution bearing on the major research topic of the late Professor Raine, i.e. the interrelation of kidney and blood pressure.
The case for a Guytonian approach to the nephrogenesis of essential hypertension is strong [1–3]. Hypertension is not maintained in the presence of normal kidney function untrammelled by inappropriate renal vasoconstriction or by non-physiological sodium acquisitiveness. All monogenic disorders discovered to date which cause hypertension lead to inappropriate sodium
Diagnosis
Epidemiology
Pathogenesis
Treatment
References
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