Skip Navigation



NDT Advance Access published online on September 25, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp504
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Késoi, I.
Right arrow Articles by Nagy, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Késoi, I.
Right arrow Articles by Nagy, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Heart rate recovery after exercise is associated with renal function in patients with a homogenous chronic renal disease

István Késoi, Balázs Sági, Tibor Vas, Tibor Kovács, István Wittmann and Judit Nagy

Nephrology Center and 2nd Department of Internal Medicine, Medical Faculty, University of Pécs, Hungary

Correspondence and offprint requests to: Judit Nagy; E-mail: judit.nagy{at}aok.pte.hu



  Abstract

Background. Attenuated heart rate recovery (HRR) is an independent predictor of cardiac and total mortality. Diminished renal function is a similar predictor. There are no data concerning the interaction between the two risk factors. We studied HRR in patients with a homogeneous renal disease, IgA nephropathy.

Methods. One hundred and seven patients with biopsy-proven chronic IgA nephropathy (71 males, 36 females aged 45 ± 11 years) performed a graded exercise treadmill stress test. HRR was measured as the heart rate difference between the peak value and the heart rate 1 min after exercise. The patients were divided into three groups based on estimated glomerular filtration rate (eGFR): CKD 1, eGFR ≥ 90 ml/min (n = 46); CKD 2, eGFR 60–89 ml/min (n = 38), CKD 3–4, eGFR 15–59 ml/min (n = 23). We compared these data with 29 normal controls (aged 46 ± 14 years).

Results. HRR values corresponded to eGFR as follows: 29.9 ± 8.8 bpm normal controls, 27.8 ± 9.2 bpm CKD 1, 24.5 ± 10.5 bpm CKD 2 and 16.3 ± 9.3 bpm CKD 3–4. The latter differed from the other groups significantly (P < 0.05). Metabolic syndrome was common in IgA nephropathy patients (27%). Metabolic syndrome patients had a HRR of 19.6 ± 10.1 bpm, compared to 25.8 ± 10.4 bpm in patients without metabolic syndrome (P = 0.007). Nevertheless, a multivariate regression analysis accepted only eGFR as an independent predictor of HRR.

Conclusion. eGFR predicts HRR in patients with a homogenous renal disease. Metabolic syndrome influences HRR, albeit not independently in this cohort.

Keywords: cardiovascular risk; chronic kidney disease; heart rate recovery; IgA nephropathy; metabolic syndrome

Received for publication: 8. 3.09
Accepted in revised form: 31. 8.09


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.