Skip Navigation



NDT Advance Access published online on September 25, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp498
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Park, J. T.
Right arrow Articles by Kang, S.-W.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Park, J. T.
Right arrow Articles by Kang, S.-W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Metabolic syndrome predicts mortality in non-diabetic patients on continuous ambulatory peritoneal dialysis

Jung Tak Park1, Tae Ik Chang1, Dong Ki Kim2, Jung Eun Lee1, Hoon Young Choi1, Hyun Wook Kim1, Jae Hyun Chang1, Sun Young Park1, Eunyoung Kim1, Tae-Hyun Yoo1, Dae-Suk Han1 and Shin-Wook Kang1

1 Department of Internal Medicine, College of Medicine, Brain Korea 21 for Medical Science, Yonsei University 2 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Correspondence and offprint requests to: Shin-Wook Kang; E-mail: kswkidney{at}yuhs.ac



  Abstract

Background. Metabolic syndrome is associated with higher morbidity and mortality in the general population, but the corresponding effects in patients on dialysis have not been clearly defined. In this study, we prospectively investigated the effect of metabolic syndrome and its individual components on outcome in non-diabetic peritoneal dialysis (PD) patients.

Method. The study subjects included 106 stable non-diabetic PD patients who had been on PD for >3 months. We measured baseline characteristics, blood pressure, fasting blood glucose, lipid profiles and high-sensitivity CRP (hsCRP), and defined metabolic syndrome using the modified National Cholesterol Education Program (Adult Treatment Panel III) criteria. Mortality, technical failure and hospitalization were evaluated during the follow-up period.

Results. Metabolic syndrome was present in 50 patients (47.2%), and these showed higher baseline hsCRP levels (0.67; 95% CI: 0.50–0.94 versus 1.78 mg/dl; 95% CI: 1.21–2.57; P < 0.001). Patients with metabolic syndrome experienced significantly lower 5-year survival rates than patients without (90% versus 67%, P = 0.02), although these groups did not differ in peritonitis rates, technical failure or hospitalization. A Cox proportional hazards analysis identified the following as predictors of mortality: metabolic syndrome (RR: 3.39; 95% CI: 1.16–9.94; P = 0.02), baseline albumin (RR: 0.06; 95% CI: 0.01–0.30; P = 0.001) and baseline hsCRP levels (RR: 1.14; 95% CI: 1.07–1.22; P < 0.001).

Conclusion. Metabolic syndrome is prevalent and is a risk factor influencing long-term survival in non-diabetic PD patients.

Keywords: inflammation; metabolic syndrome X; mortality; peritoneal dialysis

Received for publication: 12. 5.09
Accepted in revised form: 27. 8.09


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.