Skip Navigation



NDT Advance Access published online on September 11, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp469
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bayat, S.
Right arrow Articles by Frimat, L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bayat, S.
Right arrow Articles by Frimat, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Survival of transplanted and dialysed patients in a French region with focus on outcomes in the elderly

Sahar Bayat1, Michèle Kessler2, Serge Briançon1 and Luc Frimat1,2

1 Department of Clinical Epidemiology and Evaluation, Nancy University 2 Department of Nephrology, Hôpitaux de Brabois, University Hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France

Correspondence and offprint requests to: Luc Frimat; E-mail: l.frimat{at}chu-nancy.fr



  Abstract

Background. Impact of kidney transplantation on survival of French end-stage renal disease (ESRD) patients is unknown.

Methods. A total of 1495 adults living in the Lorraine region and starting renal replacement therapy from 1997 to 2003 were included. A propensity score (PS) of registration on the renal transplant waiting list was estimated. Patient survival was studied using a time-dependent Cox multivariate regression and a Cox model stratified by PS tertiles. Survival of older patients (≥60 years) was detailed.

Results. Survival was associated with age, medical factors and transplantation. The hazard ratio (HR) of death for patients on dialysis compared to transplant recipients was 4.6 (95% CI: 2.9–7.2). The survival analysis stratified by PS was similar to the multivariate Cox model. The survival benefit of transplantation over dialysis persisted among elderly patients [HR: 4.6 (95% CI: 2.2–9.7)].

Conclusions. In a French community-based network, after taking into account comorbidities, transplantation was associated with longer survival even among elderly patients. Age per se should not therefore be considered as a contraindication to renal transplantation. However, elderly patients should be evaluated carefully before registration on the list. Medical guidelines should put forward a standard set of criteria for access to renal transplantation.

Keywords: dialysis; kidney transplantation; survival

Received for publication: 7. 4.09
Accepted in revised form: 17. 8.09


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.