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NDT Advance Access published online on August 4, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp373
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Age-independent association between arterial and bone remodeling in mild-to-moderate chronic kidney disease

Marie Briet1,2,3, Gérard Maruani3, Cédric Collin1,2, Erwan Bozec1,2, Cédric Gauci3, Pierre Boutouyrie1,2, Pascal Houillier1,3, Stéphane Laurent1,2 and Marc Froissart1,3

1 Université Paris Descartes, INSERM, UMR872, Paris, F-75006 2 Department of Pharmacology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou 3 Department of Physiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, F-75015 France

Correspondence and offprint requests to: Marie Briet; E-mail: mariebriet1{at}free.fr



  Abstract

Background. Damages to large arteries are related to bone disease in end-stage renal disease and contribute to cardiovascular mortality. An outward remodeling and stiffening of carotid artery already exist at an earlier stage of chronic kidney disease (CKD). We made the hypothesis that bone disease could be associated with the carotid outward remodeling in parallel with the decline of renal function in this population.

Methods. One hundred and seven patients (60.4 ± 14.6 years) with CKD (mean glomerular filtration rate = 34 ± 17 mL/min/1.73 m2) were included in this cross-sectional study. Common carotid artery diameter, intima–media thickness and carotid stiffness were determined with an echotracking system. Bone evaluation was performed by bone densitometry and the measurement of a bone-remodeling marker, bone-specific alkaline phosphatase (BSALP).

Results. After adjustment for age, sex, mean blood pressure, carotid pulse pressure and glomerular filtration rate, bone mineral densities measured at the radius, hip and lumbar spine were significantly and negatively correlated with carotid internal diameter (P = 0.0001, P = 0.0003, P = 0.01, respectively). This association exists only in patients with glomerular filtration rate ≤38 mL/min/ 1.73 m2. BSALP was independently and positively correlated with carotid internal diameter and explained 13% of the variance.

Conclusions. Bone mineral density and serum marker of bone remodeling are independently correlated with arterial remodeling in CKD patients suggesting a crosstalk between kidney, arterial wall and bone.

Keywords: arterial remodeling; arterial stiffness; bone mineral density; chronic kidney disease; echotracking

Received for publication: 10. 3.09
Accepted in revised form: 6. 7.09


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