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NDT Advance Access published online on June 25, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp296
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Simultaneous occurrence of hepatitis C virus-associated glomerulonephritis and AL amyloidosis

Yali Cao, Youkang Zhang, Suxia Wang, Minghui Zhao and Wanzhong Zou

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, 100034, People's Republic of China

Correspondence and offprint requests to: Youkang Zhang; E-mail: zyk2467{at}sohu.com



  Abstract

We report a 65-year-old male with hepatitis C virus (HCV)-associated glomerulonephritis (GN) and AL amyloidosis. This patient had a 14-year history of HCV infection with positive serum HCV RNA at presentation. Diagnosis of HCV-related GN was established using immunohistochemistry in which the HCV-NS3 antigen was mainly detected as granular deposition in glomerular mesangium. AL amyloidosis was determined by electron microscopy, positive Congo red staining and identification of {lambda}-chain in the kidney specimen and monoclonal IgG-{lambda} in serum and urine. Under immunoelectron microscopy, the HCV-NS3 antigen was found in electron-dense deposits, while {lambda}-chains appeared in the amyloid-like filaments.

Keywords: AL amyloidosis; glomerulonephritis; hepatitis C virus

Received for publication: 14. 4.09
Accepted in revised form: 26. 5.09


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