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NDT Advance Access published online on November 28, 2008
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn661
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Vitiligo following a combined liver–kidney transplant

Victoria Bradley1, Elizabeth Helen Kemp2, Claire Dickinson1, Tim Key3, Paul Gibbs4 and Menna R. Clatworthy5

1 Cambridge School of Clinical Medicine 2 School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield 3 Tissue Typing Laboratory, Addenbrooke's Hospital, Cambridge 4 Department of Surgery, University of Cambridge 5 Division of Renal Medicine, Department of Medicine/Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK

Correspondence and offprint requests to: Menna R. Clatworthy, Lab 4.15 CIMR, Box 139 Addenbrooke's Hospital, Cambridge CB2 2XY, UK. Tel: +44-1223-762639; Fax: +44-1223-762640; E-mail: mrc38{at}cam.ac.uk



  Abstract

We report an Afro-Caribbean male who developed vitiligo 10 days following a combined liver–kidney transplant from a Caucasian donor. Neither the donor nor the recipient had any previous history of vitiligo, nor of autoimmunity. The depigmentation gradually resolved by 8 weeks post-transplant with topical corticosteroids and standard maintenance immunosuppression. We propose that the skin depigmentation occurred due to the destruction of melanocytes by donor-derived alloreactive cytotoxic T-lymphocytes or antibody transferred during transplantation. Although vitiligo has been described in patients receiving allogeneic bone marrow transplantation for haematological malignancy, there are no previous reports of vitiligo post-solid organ transplantation.

Keywords: autoimmunity; liver–kidney transplant; vitiligo

Received for publication: 30.10.08
Accepted in revised form: 3.11.08


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