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NDT Advance Access published online on November 27, 2008
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn625
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Biopsy proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?

Simon K. Winn1, Sarah Ellis2, Philip Savage2, Stephen Sampson3 and James E. Marsh1

1 Department of Renal Medicine, St Helier Hospital, Carshalton, Surrey SM5 1AA 2 Department of Medical Oncology, Charing Cross Hospital, London W6 8RF 3 Department of Histopathology, St Helier Hospital, Carshalton, Surrey SM5 1AA, UK

Correspondence and offprint requests to: Simon K. Winn, Department of Renal Medicine, St Helier Hospital, Carshalton, Surrey SM5 1AA, UK. Tel: +0208-296-3698; +0208-644-8257; E-mail: simon.winn{at}epsom-sthelier.nhs.uk



  Abstract

Since their introduction in 2006, the tyrosine kinase inhibitors (TKI) Sunitinib and Sorafenib have become the standard of care for many patients with renal cancer. They are generally well tolerated and have not been significantly implicated in renal toxicity. We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer. However, two previous descriptions of interstitial nephritis related to treatment with TKIs, combined with this current report suggest that TKI therapy could be associated with this rare but life-threatening complication.

Keywords: acute interstitial nephritis; renal cell carcinoma; sunitinib; tyrosine kinase inhibitors

Received for publication: 13.10.08
Accepted in revised form: 15.10.08


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