NDT Advance Access published online on April 11, 2008
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn158
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Marked variation in the definition and diagnosis of delayed graft function: a systematic review
1 Section of Nephrology and Clinical Epidemiology Research Center, Yale School of Medicine and VAMC, New Haven, CT, USA 2 London Health Sciences Center, Ontario, Canada 3 Department of Internal Medicine, Wayne State University, Detroit, MI 4 Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 5 Department of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA, USA
Correspondence and offprint requests to: Chirag Parikh, Section of Nephrology, Yale University and VAMC, 950 Campbell Ave., Mail Code 151B, Bldg 35 A, Room 219, West Haven, CT 06516, USA. Tel: +1-203-932-5711 Ext. 4300; Fax: +1-203-937-4932; E-mail: chirag.parikh{at}yale.edu
 |
Abstract |
|---|
Background. The term delayed graft function (DGF) is commonly used to describe the need for dialysis after receiving a kidney transplant. DGF increases morbidity after transplantation, prolongs hospitalization and may lead to premature graft failure. Various definitions of DGF are used in the literature without a uniformly accepted technique to identify DGF.
Methods. We performed a systematic review of the literature to identify all of the different definitions and diagnostic techniques to identify DGF.
Results. We identified 18 unique definitions for DGF and 10 diagnostic techniques to identify DGF.
Conclusions. The utilization of heterogeneous clinical criteria to define DGF has certain limitations. It will lead to delayed and sometimes inaccurate diagnosis of DGF. Hence a diagnostic test that identifies DGF reliably and early is necessary. Heterogeneity, in the definitions used for DGF, hinders the evolution of a diagnostic technique to identify DGF, which requires a gold standard definition. We are in need of a new definition that is uniformly accepted across the kidney transplant community. The new definition will be helpful in promoting better communication among transplant professionals and aids in comparing clinical studies of diagnostic techniques to identify DGF and thus may facilitate clinical trials of interventions for the treatment of DGF.
Keywords: delayed graft function; definition; diagnosis
Received for publication: 29.12.07
Accepted in revised form: 28. 2.08
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Kruger, S. Krick, N. Dhillon, S. M. Lerner, S. Ames, J. S. Bromberg, M. Lin, L. Walsh, J. Vella, M. Fischereder, et al. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation PNAS, March 3, 2009; 106(9): 3390 - 3395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Yarlagadda, S. G. Coca, R. N. Formica Jr, E. D. Poggio, and C. R. Parikh Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis Nephrol. Dial. Transplant., March 1, 2009; 24(3): 1039 - 1047. [Abstract] [Full Text] [PDF]
|
|