Nephrol Dial Transplant (1994) 9: 698-703
© 1994 European Renal Association-European Dialysis and Transplant Association
research-article
Low-dose OKT3 induction therapy following renal transplantation: a controlled study
Renal Transplant Unit and Clinical Immunology Unit, Department of Internal Medicine, Academic Medical Center, University of Amsterdam The Netherlands
Correspondence and offprint requests to: Correspondence and offprint requests to: P. Th. A. Schellekens, Department of Internal Medicine F4-222, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
In a prospective clinical study we tested the immunosuppressive properties and toxicity of low-dose OKT3 induction therapy in renal transplant recipients. 50 consecutive renal transplant recipients were alternat ingly assigned to low-dose OKT3 induction or prednisolone/cyclosporin. Low-dose OKT3 induction treatment consisted of 0.5 mg OKT3 twice daily for 10 days, initially combined with azathioprine and prednisolone maintenance immunosuppression that was converted to prednisolone/cyclosporin at the end of the course. During a 15–29-month follow-up period, low-dose OKT3 induction therapy was found to reduce significantly the incidence of acute rejections, as com-pared to the usual prednisolone/cyclosporin mainten ance immunosuppression (21 versus 52%, P=0.02). There also was a tendency towards an improved graft function after low-dose OKT3, although no signific ance was reached. Furthermore, compared to a histor ical control group of renal transplant patients in whom acute rejection was treated with 5 mg OKT3 daily, low-dose OKT3 appeared to cause fewer side-effects. We conclude that low-dose OKT3 induction therapy is superior to prednisolone/cyclosporin in preventing acute rejection after renal transplantation and that it is better tolerated than conventional OKT3 treatment.
Keywords: immunosuppression; induction treatment; low-dose OKT3; renal transplantation