Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hess, B.
Right arrow Articles by Jaeger, Ph.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hess, B.
Right arrow Articles by Jaeger, Ph.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1994) 9: 642-649
© 1994 European Renal Association-European Dialysis and Transplant Association

research-article

Risk factors for low urinary citrate in calcium nephrolithiasis: low vegetable fibre intake and low urine volume to be added to the list

B. Hess1,, R. Michel1, R. Takkinen1, D. Ackermann2 and Ph. Jaeger1

1Policlinic of Medicine University Hospital Berne, Switzerland 2Department of Urology, University Hospital Berne, Switzerland

Correspondence and offprint requests to: Correspondence and offprint requests to: B. Hess MD, Policlinic of Medicine, University Hospital, CH-3010 Berne, Switzerland

Risk factors for low urinary citrate excretion were assessed in 34 consecutive male recurrent idiopathic calcium stone formers (RCSF) who collected two 24-h urines while on free-choice diet. Overt hypocitraturia (hypo-cit) was defined as UCitxV<1.70 mmol/day, and ‘low’ citraturia (low-cit) as UCitxV between 1.70 and 2.11 mmol/day. Twenty-three RCSF had normocitraturia (normo-cit), six low-cit and five hypo-cit. UCitxV positively correlated with urine volume (VOLUME, r=0.44, P=0.009), vegetable fibre intake (fibers, r=0.46, P=0.009) and GI-alkali absorption (alkali, r=0.47, P=0.006), and volume, fibres and alkali tended to be lower among RCSF with low-/hypo-cit. A 3-day NH4Cl loading test (0.95 mEq/kg BW daily in 3 doses) was performed in RCSF as well as in 14 age-matched healthy male controls (C). On a plot of urine pH versus serum bicarbonate, 10 of 11 RCSF with low-/hypo-cit, but only six of 23 with normo-cit (P=0.0004) fell off the normal range, indicating incomplete RTA. Two or more risk factors simultaneously occurred in only four of 23 RCSF with normo-cit, but in eight of 11 with low-/hypo-cit (P= 0.002). In conclusion, incomplete RTA is the most prevalent risk factor for low-/hypo-cit in RCSF, and decreases in vegetable fibres and urine volume emerge as two new risk factors for low urinary CIT.

Keywords: calcium nephrolithiasis; citrate; gastrointestinal alkali absorption; renal tubular acidosis; urine volume; vegetable fibres


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
A. Glauser, W. Hochreiter, P. Jaeger, and B. Hess
Determinants of urinary excretion of Tamm-Horsfall protein in non-selected kidney stone formers and healthy subjects
Nephrol. Dial. Transplant., October 1, 2000; 15(10): 1580 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
K. Aasarod, H.-J. Haga, K.J. Berg, J. Hammerstrom, and S. Jorstad
Renal involvement in primary Sjogren's syndrome
QJM, May 1, 2000; 93(5): 297 - 304.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.