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Nephrol Dial Transplant (1993) 8: 744-747
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Antibodies to hepatitis C virus (HCV) and transaminase concentration in chronic haemodialysis patients: a study with second-generation assays

F. Fabrizi1,, L. Raffaele2, G. Bacchini1, I. Guarnori2, G. Pontoriero1, G. Erba2 and F. Locatelli1

1Department of Nephrology Lecco, Italy 2Transfusion Centre, Hospital Lecco, Italy

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr F Fabnzi, Division of, Dept of Nephrology, Nephrology and dialysis, Transfusion Centre, Hospital of Lecco, via Ghislanzoni 22, 22053 Lecco, Italy.

We used first- and second-generation assays such as Ortho I, Ortho 2 and 4-RIBA to define prevalence and nsk factors for anti-HCV antibodies in haemodialysed patients. Forty-nine (24%) subjects were found to be anti-HCV positive. Anti-HCV positiv ity was related to duration of dialysis and past or current elevations of GOT and GPT; the frequency of transfused patients was greater in HCV-positive than in HCV-negative subjects; there were 31 patients (pre valence of 20%) with anti-HCV antibodies among non-transfused patients. These findings show that, tested by second-generation assays, HCV infection is detected more than twice as commonly in haemodia lysis patients and may be responsible for a significant proportion of liver disease in this clinical setting Acquisition of hepatitis C virus by dialysis patients is not only through blood transfusions but also secondary to hepatitis C virus presence within the unit itself.

Keywords: hepatitis C virus; transaminase levels; haemodialysis


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