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Nephrol Dial Transplant (1993) 8: 684-689
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Chronic renal failure in India

M. K. Mani

Renal Unit, Apollo Hospital Madras, India

Correspondence and offprint requests to: Correspondence and offprint requests to: M. K Mani, Chief Nephrologist, Apollo Hospital, 21, Greams Lane, Madras 600006, India.

In a series of 2028 patients with chronic renal failure, the diseases leading to renal failure, the presence or absence of reversible factors and their nature, and the rate of decline of renal function of the most common conditions have been described and analysed. Seven diseases: chronic interstitial nephritis (27.85%), diabetic nephropathy (26.76%), chronic glomerulonephritis (18.20%), benign nephrosclerosis (10.06%), chronic pyelonephritis (7.29%), focal glom erulosclerosis (3.20%), and autosomal dominant poly cystic disease of the kidneys (2.07%), accounted for 95.43% of all the patients. These diseases were studied in greater detail and the results are presented here. It was found that there was a great variation in the rate of decline of renal function in the different groups, with chronic glomerulonephritis and focal glomerular sclerosis progressing most rapidly, diabetic nephro pathy slightly slower, and the others at a less alarming pace. However, once serum creatinine had reached 177 µmol/l there was an inexorable decline in renal function and the end stage was reached in almost all patients.

Keywords: chronic renal failure; causes; rate of decline in renal function; reversible deterioration of renal function


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