Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Huraib, S.
Right arrow Articles by Al-Swailem, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huraib, S.
Right arrow Articles by Al-Swailem, A. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1993) 8: 603-608
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Pattern of renal osteodystrophy in haemodialysis patients in Saudi Arabia

S. Huraib1,, M. Z. Souqqiyeh2, S. Aswad3 and A. R. Al-Swailem4

1Division of Nephrology, Department of Medicine, King Khalid University Hospital Riyadh, Saudi Arabia 2Riyadh Central Hospital Riyadh, Saudi Arabia 3National Kidney Foundation Riyadh, Saudi Arabia 4Ministry of Health Riyadh, Saudi Arabia

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr Sameer Omar Huraib MBBS FRCP(C) FACP Division of Nephrology, Dept. of Medicine (38), King Khalid University Hospital, P.O. Box 2925, Riyadh 11472, Saudi Arabia

In order to know the pattern of renal osteodystrophy in haemodialysis patients in Saudi Arabia we conducted a multicentre study involving 209 patients. The mean age of the patients was 39.4±14 (18–70) years, 128 were males and 81 females. All patients were on acetate dialysate and their mean duration on dialysis was 3.5 ± 1.5 years.

The major symptom was bone and joint pain (25.8%). The mean serum calcium was 2.1 ±0.26 mmol/l, phosphorus 2.0 ±0.36 mmol/l, alkaline phosphatase 19.7± 14.6 u/l and parathyroid hormone level was 8.9 ± 3.9mg/ml. The mean serum aluminium (AL) level was 25.4±17.7 µg/l, while that of 1,25 vitamin D3 was 8.1±4.2ng/l and of fluoride was 92.2 ± 31.4 µg/l. The major radiological finding was osteosclerosis (70%). Dual-photon absorptiometry (DPA) showed low bone mineral density (LBM) in 65% of the patients.

Forty-one patients had bone biopsies with AL staining of the biopsies. Of this group, 92% had changes of hyperparathyroidism and 66% of them were pure hyperparathyroidism. Sixty percent of them had variable degrees of AL intoxication. The radiological skeletal survey of those patients could detect abnormalities in only 46% while 70% of them had abnormal bone mineral density (BMD).

In conclusion, osteosclerosis is the commonest radiological finding in our dialysis patients while secondary hyperparathyroidism is the main histopathological diagnosis in bone biopsy, even in patients with normal skeletal survey. AL intoxication is a significant problem in our population. DPA is more sensitive in detecting bone abnormalities than X-radiography.

Keywords: renal osteodystrophy; haemodialysis; acetate dialysis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.