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Nephrol Dial Transplant (1993) 8: 1254-1258
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Gingival overgrowth among renal transplant recipients and uraemic patients

H. E. Pernu1,, L. M. H. Pernu1, M. L. E. Knuuttila1 and K. R. H. Huttunen2

1Institute of Dentistry. University of Oulu Oulu. Finland 2Department of Mcdicine, University Central Hospital Oulu. Finland

Correspondence and offprint requests to: Correspondence and offprint requests to: H E Pernu. lnstitute of Dentistry. University of Oulu. Aappistie 3. SF-90220 Oulu. Flnland

No detailed data exist on an association between combined cyclosporin (CsA) and dihydropyridine (DHP) medication and gingival overgrowth among renal patients. Thirty-five renal transplant recipients treated with CsA and 28 uraemic patlents participated In this research. Fourteen of the recipients and 14 of the uraemic patients were receiving DHP. The examination included determination of the duration of the CsA and DHP treatment protocols, the mean daily oral dose of DHP, and periodontal status. Gingival overgrowth was classified into four categories according to the clinical changes: score 0=no gingival overgrowth, score 1=mild gingival overgrowth, score 2=moderate gingival overgrowth, and score 3=severe gingival overgrowth. The prevalence of clinically obvious gingival overgrowth (scores 2 and 3) was 35% in those treated with CsA and DHP, 24% with CsA and 21% with DHP. The concomitant administration of CsA and DHP resulted in a significantly increased percentage of scores 2 and 3 overgrown gingival units as compared with DHP alone (P<0.05). Gingival overgrowth (scores 1 , 2, 3) did not correlate with either the dally oral dose of DHP or the duration of DHP treatment. Combined treatment with CsA and DHP did not significantly Increase the prevalence of glngival overgrowth, but it did increase the severity of itiamong susceptible patients.

Keywords: cyclosponn; dihydropyridine; ginglval overgrowth; renal transplantation; uraemia


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 Nephrol Dial TransplantHome page
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