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Nephrol Dial Transplant (1993) 8: 1215-1218
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

Does erythropoietin cause hormonal changes in haemodialysis patients?

G. Steffensen and N. Aa Aunsholt

Department of Medicine C, Aalborg Hospital Aalborg, Denmark

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr G. Steffensen, Department of Medicine C, Aalborg Hospital, 9000 Aalborg, Denmark

In 10 female and 10 male haemodialysis patients plasma FSH, LH, testosterone, prolactin, and somatotropin (STH) were estimated during erythropoietin (rHuEpo) treatment for 6 months. All but one patient responded with an increase in haemoglobin. The patients experienced improved sexual function according to the answers given in a self-administered questionnaire. Of the 90% who answered before the study 22% could not perform sexual activities whether they wanted to or not. During and at the end of the study 80 and 60% respectively answered, and none had these problems. In contrast, serum values of the sexual hormones (FSH, LH, testosterone and prolactin) were not significantly changed during rHuEpo therapy, and neither was the basal plasma STH.

Keywords: erythropoietin therapy; haemodialysis; sex hormones; somatotropin


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