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Nephrol Dial Transplant (1993) 8: 1211-1214
© 1993 European Renal Association-European Dialysis and Transplant Association

research-article

CR1 activity on erythrocytes and renal glomeruli in patients with renal disorders

B. M. Iversen1,, C. A. Vedeler2, R. Matre3 and E. Svarstad1

1Renal Research Group, Medical Department A, Gade Institute, University of Bergen Norway 2Department of Neurology, Gade Institute, University of Bergen Norway 3Department of Microbiology and Immunology, Gade Institute, University of Bergen Norway

Correspondence and offprint requests to: Correspondence and offprint requests to: B. M. Iversen, Med. Dept. A. N-5021 Haukelandsykehus, Norway

Complement receptors for C3b/C4b (CRI) on erythrocytes (ERC1) and renal glomeruli (GCR1) were examined in patients with different types of renal disorders. Normal ECR1 activity was found on erythrocytes from patients with IgA glomerulonephritis, benign nephrosclerosis and other types of renal diseases. In patients with systemic lupus erythematosus (SLE) and glomerulonephritis ECRl activity was low or absent in 75% of the patients. The GCR1 activity, however, was normal except in areas with complement deposits where GCR1 activity was abolished. During treatment with corticosteroids and azathioprine of patients with SLE the clinical response was followed by increased functional ECR1 activity. In those patients who did not respond the ECR1 activity was persistently low. Three patients with renal transplant all showed increased ECR1 activity.

Keywords: complement receptors; SLE glomerulonephritis; renal transplantation


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