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Nephrol Dial Transplant (1992) 7: 636-641
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

Lipid and lipoprotein (a) concentrations in renal ransplant patients

A. T. Web, M. Plan, D. A. Reaveley, M. O'Donnell, V. A. Luck, B. O'Connor, M. Seed and E. A. Brown

Charing Cross and Westminster Medical School, Charing Cross Hospital London, UK

Correspondence and offprint requests to: Correspondece and offprint requests to: Dr A. T. Webb, Department of Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK

Lipid and lipoprotein concentrations, including lipoprotein (a), were measured in 67 clinically stable renal allograft recipients and compared with age- and sex-matched controls. Median lipoprotein (a) concentrations were significantly elevated in the transplant group (P = 0.048), with the distribution of apoprotein (a) isoforms being similar between the two groups. The transplant group also demonstrated significant elevations in cholesterol (P<0.0001), triglycerides (P = 0.0007) and low-density lipoprotein cholesterol (P< 0.0001). There was no significant difference in high-density lipoprotein cholesterol concentrations between the groups although there was the expected tendency for higher values in females. Lipoprotein abnormalities are common following renal transplantation and these patients also demonstrate elevated lipoprotein (a) values. This unique lipoprotein is known to be atherogenic and may contribute to the development of vascular disease, which is a common mode of death in these patients

Keywords: atherosclerosis; cyclosporin; isoform; lipoprotein (a); transplant


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