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Nephrol Dial Transplant (1992) 7: 618-622
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

Does haemodialysis impair macrophage Fc receptor function?

C. Halma1,, M. R. Daha1, R. I. J. Feitsma2, M. S. T. van Holthe3, J. H. Evers-Schouten1, E. K. J. Pauwels2 and L. A. van Es1

1Department of Nephrology, University Hospital Leiden Leiden, The Netherlands 2Division of Nuclear Medicine, Department of Diagnostic Radiology, University Hospital Leiden Leiden, The Netherlands 3Department of Dietetics, University Hospital Leiden Leiden, The Netherlands

Correspondence and offprint requests to: Correspondence and offprint requests to: C. Halma, MD, Department of Nephrology, C3P, Bldg. 1, University Hospital Leiden, P.O. Box 9600, 2300 RC Leiden, The Netherlands

Patients treated with chronic haemodialysis are at risk of infections, possibly because of impaired function of macrophage Fc receptors. Using [123I]-labelled aggregates of human IgG ([123I]-AIgG) as a probe of Fc-receptor-mediated function, we examined eight patients treated with chronic intermittent haemodialysis (HD), eight patients treated with CAPD, eight patients with preterminal renal failure who had not yet received renal replacement therapy, and eight healthy controls. In all three patient groups the first elimination half-life of [123I]-AIgG was decreased, suggesting accelerated binding of the probe. In the HD group overall clearance of [123I]-AlgG was similar to the value found in healthy controls. In the CAPD and preterminal renal failure group clearance was decreased as compared with the HD patients. Uptake of [123I]-AIgG by liver and spleen was quantitatively similar in patients and controls, but hepatic uptake of [123I]-AIgG reached its maximum earlier in the patients treated with HD. These results suggest that Fc receptor function is not impaired in patients who undergo chronic haemodialysis.

Keywords: CAPD; Fc receptor function; haemodialysis; mononuclear phagocyte system; renal failure


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