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Nephrol Dial Transplant (1992) 7: 251-255
© 1992 European Renal Association-European Dialysis and Transplant Association

research-article

Reduced erythrocyte and leukocyte magnesium is associated with cyclosporin treatment and hypertension in renal transplant patients

I. Al-Khursany, T. H. Thomas1,, K. Harrison2 and R. Wilkinson1

1Department of Nephrology, Freeman Hospital, Department of Medicine, University of Newcastle-upon-Tyne 2Department of Clinical Biochemistry, Royal Victoria Infirmary Newcastle-upon-Tyne, UK

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr T. H. Thomas, Nephrology Research Laboratories, Podium Level 4, Freeman Hospital, Freeman Road, Newcastle-upon-Tyne, NE7 7DN, UK.

Plasma, urine, erythrocyte and leukocyte magnesium were measured in normotensive and hypertensive renal transplant patients who were being treated with either azathioprine or cyclosporin. These were compared with essential hypertensive patients and normal subjects. Erythrocyte and leukocyte magnesium were reduced in renal transplant patients in independent association (ANOVA) with both cyclosporin treatment (P = 0.03, P = 0.0/6 respectively) and hypertension (P< 0.001 for both). Therefore, hypertensive transplant patients on cyclosporin had the lowest magnesium content of both erythrocytes (1.22±0.09mmol/1 cells) and leukocytes (2.68 ± 0.2 nmol/106 cells) compared to normal subjects (1.96 ±0.17 and 4.1 1 ±0.58 respectively) whereas normotensive transplant patients on azathioprine had normal values (2.12±0.16 and 5.13±1.0 respectively). Plasma magnesium was also reduced with cyclosporin treatment. Urine magnesium was not significantly different between any of the groups. Therefore, magnesium depletion may have a role in hypertension in renal transplant patients. Since cyclosporin treatment is also associated with magnesium depletion, this could explain the increased occurrence of hypertension in these patients.

Keywords: azathioprine; cyclosporin; erythrocyte; hypertension; leukocyte; magnesium


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