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Nephrol Dial Transplant (1989) 4: 829-830
© 1989 European Renal Association-European Dialysis and Transplant Association

other

Phosphate Binding Efficiency of a Polyuronic Acid in Normal Subjects

N. A. T. Hamdy, E. V. McCloskey, V. A. Naylor, C. B. Brown and J. A. Kanis

Departments of Human Metabolism and Clinical Biochemistry, Nephrology and Dietetics. University of Sheffield Medical School Sheffield, UK

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr J. A. Kanis, Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK Tel: 0742 739176

We evaluated the phosphate-binding efficiency of Sorbiphos, a non-toxic aluminium-free natural polymer, in five volunteers aged 28–34 years with normal renal function. After an overnight fast, a placebo, 2 g of Sorbiphos or a therapeutic dose of Alu-Cap (950 mg) were given, 30 min before a dietary load of phosphorus. Serum and urinary phosphate were measured on hourly samples. A similar increment in serum and urine phosphate was noted after the ingestion of placebo or Sorbiphos, but both serum and urine phosphate increased less after Alu-Cap. Since the recommended dose of Sorbiphos is half that of Alu-Cap, we conclude that Sorbiphos has little phosphate-binding efficiency in normal subjects given moderate phosphate loads.

Keywords: Aluminium-free phosphate binder; Aluminium hydroxide; Normal subjects


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