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Nephrol Dial Transplant (1989) 4: 805-813
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

Peritoneal Ultrafiltration and Fluid Reabsorption During Peritoneal Dialysis

B. Lindholm1,, O. Heimb{diaeresis}rger1, J. Waniewski2, A. Werynski2 and J. Bergström1

1Department of Renal Medicine, Karolinska Institute, Huddinge University Hospital Stockholm, Sweden 2Institute of Biocybernetics and Biomedical Engineering Warsaw, Poland

Correspondence and offprint requests to: Correspondence and offprint requests to: Bengt Lindholm, Department of Renal Medicine K56, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden. Tel: 46-8-7462755

Peritoneal ultrafiltration and fluid reabsorption characteristics for 18 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were investigated in single dwell studies of 6 h duration with 21 of 3.86% glucose dialysis fluid. Dialysate volumes were determined in situ using radioiodinated serum albumin (RISA) as volume marker with a correction applied for the total elimination of RISA from the peritoneal cavity. The RISA elimination rate was calculated as 2.1±0.5 ml/min. The true dialysate volume after 360 min was on average 28% less than the apparent volume calculated without correction for the elimination of RISA. The mean maximum true volume plus sampling losses was 3255 ml at 240 min, corresponding to a mean net ultrafiltration volume of 762 ml between 3 min and 240 min. The mean net fluid reabsorption rate between 240 min and 360 min was 1.2±0.7 ml/min. This study of standard dialysate volume/time curves in clinically stable CAPD patients using hypertonic dialysis fluid shows that about 90% of the total net ultrafiltration is achieved during the first 90 min of the dwell. After an extended period of dialysate iso-volaemia, usually lasting as long as between 120 min and 240 min, fluid reabsorption is observed in all patients.

Keywords: Chronic renal failure; Kinetic modelling; Peritoneal volume; Peritoneal membrane; Osmotic agent


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