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Nephrol Dial Transplant (1989) 4: 787-791
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

Does Increasing Haemoglobin Concentration and Haematocrit Have a Pressor Effect in Dialysis Patients?

B. Williams1, Mair E. Edmunds1, J. P. Thompson2, P. R. Burton3, J. Feehally1 and J. Walls1,

1Leicester General Hospital Leicester, UK 2Leicester Royal Infirmary Leicester, UK 3University of Leicester Leicester, UK

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr John Walls, Department of Nephrology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK

The haemodynamic consequences of differing rates of rise of haemoglobin and haematocrit in haemodialysis and CAPD patients were examined.

Pre-dialysis mean arterial pressure, weight and haematological indices were recorded in 100 established haemodialysis patients prior to a 2-unit blood transfusion and repeated, pre-dialysis, within 1 week. Haemoglobin rose from 6.7±0.2 to 9.3±0.1 g/dl, weight was unchanged, and there was a small fall in mean arterial pressure.

Similar indices were recorded, including the mid-arm circumference (MAC) in 100 CAPD patients 1 month after starting CAPD and at the time of maximum haemoglobin within the first year. Haemoglobin rose from 8.5±0.1 to 10.7±0.1 g/dl, weight increased slightly, but there was no change in MAC: weight ratio and there was a small fall in mean arterial pressure. In neither group was there a change in antihypertensive medication.

In conclusion, increasing the haemoglobin concentration and haematocrit of dialysis patients within the range described in this study did not promote elevated blood pressure.

Keywords: Blood pressure; Dialysis; Haematocrit


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