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Nephrol Dial Transplant (1989) 4: 776-781
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

Effects of WY 47987 (Atrial Natriuretic Factor 102–126) in Patients with Renal Insufficiency: A Placebo-Controlled, Randomised Study

J. F. E. Mann, Christine Reisch, R. Bergbreiter, Daniela Karcher, E. Hackenthal, P. Vecsei, J. Nussberger and E. Ritz

Departments of Medicine and Pharmacology, University of Heidelberg, Department of Medicine, University of Erlangen-Nürnberg West Germany, andDepartment of Medicine, University of Lausanne Switzerland

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr Johannes Mann, 4. Medizin. Klinik Univ. Erlangen-Nürnberg, Kontumazgarten 14–18 D-8500 Nümberg 80. Tel. 0911-3982702

We studied renal, hormonal and cardiovascular effects of ANF 102–126 (WY 47987) in seven patients with chronic renal failure (serum creatinine 25–68 mg/1) and in four normal volunteers. ANF or placebo bolus injections were given at 1, 2, and 3 µg/kg i.v. (each dose on separate days). As compared to placebo, ANF did not induce changes of renal excretory parameters, of plasma renin and aldosterone or of blood pressure and heart rate in patients. In healthy volunteers, however, the same dose of ANF increased urinary excretion of sodium, potassium, calcium, chloride and phosphorus as well as water, and creatinine clearances, and decreased plasma aldosterone. The data suggest blunted effectiveness of ANF bolus injections in patients with renal insufficiency.

Keywords: Atrial natriuretic factor; Chronic renal failure; Blood pressure; Renal electrolyte excretion; Renin; Aldosterone


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