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Nephrol Dial Transplant (1989) 4: 1070-1075
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

Dietary Fish Oil Supplements Preserve Renal Function in Renal Transplant Recipients with Chronic Vascular Rejection

P. Sweny, D. C. Wheeler, S. F. Lui, N. S. Amin, M. A. Barradas, J. Y. Jeremy, D. P. Mikhailidis, Z. Varghese, O. N. Fernando and J. F. Moorhead

Departments of Nephrology and Chemical Pathology, Royal Free Hospital London, UK

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr David Wheeler, Institute of Nephrology. Royal Infirmary, Cardiff, Wales CF2 1SZ, UK

The effect of dietary fish oil supplements on renal failure and lipid abnormalities was studied in 14 adult renal transplant recipients with chronic vascular rejection. The rate of decline of renal function (assessed by studying the slope of reciprocal plasma creatinine plots) slowed significantly during a 6-month period on fish oil supplements compared with the preceding 6-month control period (slope 1/cr during supplementation –3.6 x 10–5 µmol/l per month compared with –13.5 x 10–5 before, the difference in slope being –9.8 x 10–5, 95% confidence interval (CI) –16.2 x 10–5, –3.5 x 10–5, P<0.05). Total plasma triglyceride concentrations decreased during supplementation (mean change –1.15 mmol/l, 95% CI –1.84, –0.47, P<0.003), but there was no change in total plasma cholesterol concentration or urinary protein excretion. Platelet function was studied in nine patients. Platelet aggregation induced by adrenaline and collagen was reduced by fish oils (median change in per cent aggregation), adrenaline 2 µmol/ –36% (95% CI –68%, –8%, P<0.05), collagen 1 mg/l, –13% (95% CI –44%, –2%, P<0.05). Platelet thromboxane A2 release in response to these agents was also significantly reduced. These results demonstrate that fish oils preserve residual function in renal graft failure due to chronic vascular rejection.

Keywords: Chronic vascular rejection; Eicosapentaenoic acid; Fish oil; Lipids; Transplantation


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Home page
 Nutr Clin PractHome page
P. Baron and J. P. Waymack
Invited Review: A Review of Nutrition Support for Transplant Patients
Nutr Clin Pract, February 1, 1993; 8(1): 12 - 18.
[Abstract] [PDF]


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