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Nephrol Dial Transplant (1989) 4: 975-978
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

Platelet Lipid Peroxidation in Haemodialysis Patients: Effects of Vitamin E Supplementation

M. Taccone-Gallucci1,, R. Lubrano2, D. Del Principe3, Adriana Menichelli3, M. Giordani3, G. Citti4, M. Morosetti1, C. Meloni5, Valentina Mazzarella5, L. Meschini5, Carmela Tozzo1, M. Elli1, O. Giardini2 and C. U. Casciani1

1Clinica Chirurgica, II Universita' di Roma Ospedale S. Eugenio, Roma 2Clinica Pediatrica, Universita' di Roma ‘La Sapienza’, Policlinico Umberto I Roma 3Dipartimento di Sanita' Pubblica e Biologia Cellulare, II Universita' di Roma Roma 4Istituto Superiore di Sanita' Roma 5Istituto di Tipizzazione Tissutale e Problemi della Dialisi CNR L'Aquila, Italy

Correspondence and offprint requests to: Correspondence and offprint requests to: Professor Massimo Taccone-Gallucci, Dipartimento di Chirurgia, II Universita' di Roma, Via O. Raimondo 1, 00134 Roma, Italy

In haemodialysis patients, increased concentrations of malonyldialdehyde and decreased vitamin E content indicate lipid peroxidation in the platelets from oxidative damage. The same process has been described in red blood cells and in mononuclear cells in peripheral blood. However, platelet aggregation is within normal limits and does not change after treatment with vitamin E. On the other hand vitamin E supplementation reverts completely the biochemical abnormality of the platelets.

Keywords: Platelet aggregation; Malonyldialdehyde; Vitamin E; Lipid peroxidation; Haemodialysis


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