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Nephrol Dial Transplant (1989) 4: 966-970
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

Effects of Human Recombinant Erythropoietin on Anaemia, Systemic Haemodynamics and Renal Function in Predialysis Renal Failure Patients

Kaoru Onoyama, Harumitsu Kumagai, Kazuto Takeda, Kazumasa Shimamatsu and Masatoshi Fujishima

2nd Department of Internal Medicine, Faculty of Medicine, Kyushu University Fukuoka, Japan

Correspondence and offprint requests to: Correspondence and offprint requests to: Kaoru Onoyama MD, 2nd Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3, Higashi-Ku, Fukuoka city, 812 Japan

Seven anaemic patients with predialysis chronic renal failure were treated with human recombinant erythropoietin. Anaemia was improved, with a 31% increase in haematocrit, but blood pressure increased in all patients with an average of 12% in systolic (P<0.01), 14% in diastolic (P<0.05) and 13% in mean blood pressure (P<0.05). Blood volume was significantly increased by an average of 12%. Cardiac output increased in three of seven patients, and total peripheral resistance in four. GFR, RBF and RPF were not changed but filtration fraction increased significantly (P<0.05). It is suggested that blood pressure elevation might be developed as a result of volume expansion, elevated cardiac output, and increased total peripheral resistance.

Keywords: Anaemia; Glomerular filtration rate; Haemodynamics; Human recombinant erythropoietin; Hypertension; Predialysis renal failure


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R. Krapf and H. N. Hulter
Arterial Hypertension Induced by Erythropoietin and Erythropoiesis-Stimulating Agents (ESA)
Clin. J. Am. Soc. Nephrol., February 1, 2009; 4(2): 470 - 480.
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