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Nephrol Dial Transplant (1989) 4: 932-938
© 1989 European Renal Association-European Dialysis and Transplant Association

research-article

Complement Receptor (CR1) and IgG or IgA on Erythrocytes and in Circulating Immune Complexes in Patients with Glomerulonephritis

R. Coppo1,, A. Amore1, D. Roccatello1, A. Amoroso2, S. Maffei1, G. Quattrocchio1, A. Molino1, B. Gianoglio1 and G. Piccoli1

1Medical Nephrology, University of Turin, Nephrology and Dialysis Unit, Nuova Astanteria Martini Hospital Turin, Italy 2Medical Genetics, University of Turin, Nephrology and Dialysis Unit, Nuova Astanteria Martini Hospital Turin, Italy

Correspondence and offprint requests to: Correspondence and offprint requests to: Rosanna Coppo MD, Divisione di Nefrologia e Dialisi, Nuova Astanteria Martini, Piazza Donatore di Sangue 3, 10154, Torino, Italy

This study reports the quantitative analysis of complement receptor (CR1) molecules on erythrocyte surface, the amount of immunoglobulin-containing material (IgG-IC and IgA1-IM) on the erythrocyte surface, and the concentrations of circulating immune complexes (IgG-CIC and IgA-CIC); also reported are the HLA phenotypes of 44 patients affected by various forms of glomerulonephritis (including 20 primary IgA nephropathy, 11 membranous glomerulonephritis, 9 lupus nephritis and 4 renal vasculitis).

Erythrocyte CR1 molecules were found to be decreased (P<0.02) and erythrocyte IgG-IC were less than in controls (P<0.025) in lupus nephritis patients, whereas IgG-CIC were significantly greater (P<0.02).

In patients affected by primary IgA nephropathy, mean erythrocyte CR1 concentrations were significantly decreased (P<0.02). Patients with impaired renal function had mean erythrocyte CR1 values significantly greater than those with normal renal function (P<0.002). Immunoglobulin-containing material on the erythrocyte surface was not significantly increased, whereas the serum concentrations of both IgA-CIC and IgG-CIC were significantly increased (P<0.02).

In membranous nephropathy erythrocyte CR1 molecules were quantitatively similar to control data and no increase in CIC was observed. Conversely, erythrocyte IgG-IC were significantly increased (P<0.01).

No significant relationship among erythrocyte CR1 molecules, erythrocyte surface-associated immunoglobulins, CIC, and HLA phenotype was observed in any patient group.

Keywords: Glomerulonephritis; C3b receptors; CR1; Immune complexes


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