Skip Navigation


NDT Advance Access originally published online on March 4, 2009
Nephrology Dialysis Transplantation 2009 24(5):1690-1694; doi:10.1093/ndt/gfp055
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
24/5/1690    most recent
gfp055v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sanusi, A. A.
Right arrow Articles by Akinsola, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sanusi, A. A.
Right arrow Articles by Akinsola, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Relationship of ultrasonographically determined kidney volume with measured GFR, calculated creatinine clearance and other parameters in chronic kidney disease (CKD)

Abubakr A. Sanusi1, Fatiu A. Arogundade1, O. C. Famurewa2, Anthony O. Akintomide3, Folashade O. Soyinka1, Olalekan E. Ojo1 and Adewale Akinsola1

1 Renal Unit, Department of Medicine 2 Department of Radiology 3 Cardiology Unit, Department of Medicine, Obafemi Awolowo University/Teaching Hospitals Complex, Ile-Ife, Nigeria

Correspondence and offprint requests to: Abubakr A. Sanusi, Renal Unit, Department of Medicine, Obafemi Awolowo University/Teaching Hospitals Complex, Ile-Ife, Nigeria. Tel: +234-8033797190; Fax: +234-36-230141; E-mail: abubakrabefe{at}yahoo.co.uk



  Abstract

Introduction. Kidney length has traditionally been used as a predictor of chronic kidney disease (CKD); however, kidney volume (KV) rather than length has been emphasized by researchers as a true predictor of kidney size in states of good health and disease. Since KV can be assumed to be a predictor of kidney mass or remaining surviving nephrons in CKD patients, we theorized that the KV should reflect the functional capacity of the kidneys, i.e. the glomerular filtration rate (GFR).

Methodology. Forty CKD patients were recruited and investigated. Measured GFR was determined by calculating the average of endogenous creatinine clearance (mCrCl) and urea clearance (mUrCl) while predicted GFR was determined using Cockcroft and Gault, Hull and Modification of Diet in Renal Disease (MDRD) equations. KV was assessed ultrasonographically using the formulae of Dinkel et al. and Solvig et al. for ellipsoid organ. The relationship between the KV and GFR was assessed using Spearman's correlation coefficient while Bland and Altman tests were used to assess intraobserver variation and agreement between measured and predicted GFR.

Results. The results showed a weak but positive correlation between KV and various indices of GFR, best with measured CrCl (correlation coefficient ranged between 0.408 and 0.503; P < 0.05), and which was not improved after normalization for body surface area (BSA). We also found a significant correlation between the measured CrCl and various values of estimated CrCl.

Conclusion. Ultrasonographically determined KV was found to correlate with GFR and hence can be used to predict it in established CKD, particularly in resource-poor settings.

Keywords: CKD; creatinine clearance; GFR; kidney volume; MDRD

Received for publication: 11. 7.07
Accepted in revised form: 26. 1.09


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.