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NDT Advance Access originally published online on March 9, 2009
Nephrology Dialysis Transplantation 2009 24(5):1685-1689; doi:10.1093/ndt/gfp077
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Preserved residual renal function is associated with lower oxidative stress in peritoneal dialysis patients

Sophie Ignace1, Denis Fouque1,2, Walid Arkouche3, Jean-Paul Steghens4 and Fitsum Guebre-Egziabher1,2

1 Hospices Civils de Lyon, Department of Nephrology and Hypertension, Edouard Herriot Hospital 2 INSERM U870, Claude Bernard Lyon 1 University 3 AURAL 4 Hospices Civils de Lyon, Department of Biochemistry, Edouard Herriot Hospital, Lyon, France

Correspondence and offprint requests to: Sophie Ignace, Service de Néphrologie et Hypertension, Hôpital Edouard Herriot, 5, Place d’Arsonval, 69 347 Lyon Cedex 03, France. Tel: +33-4-72-11-02-02; Fax: +33-4-72-11-02-03; E-mail: sophie.ignace{at}free.fr



  Abstract

Background. Residual renal function (RRF) correlates with survival in peritoneal dialysis (PD). We investigated the association between oxidative stress and RRF in PD.

Methods. Adequacy of dialysis, total and free malondialdehydes (MDA), and lipid hydroperoxides (LHP) were obtained from 23 stable PD patients.

Results. Free MDA level decreased with total weekly Kt/ V urea (r = –0.51, P = 0.013) and urinary Kt/V (KRU) (r = –0.53, P = 0.009), but not with peritoneal Kt/V. Similar results were found with LHP level. In multivariate analysis, total weekly Kt/V urea and KRU remained associated with free MDA and LHP, independently of gender, nutritional or inflammatory status, and peritoneal permeability.

Conclusion. A preserved RRF is associated with lower serum levels of lipid peroxidation products among PD patients.

Keywords: inflammation; lipid peroxidation; oxidative stress; peritoneal dialysis; residual renal function

Received for publication: 6. 6.08
Accepted in revised form: 2. 2.09


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