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NDT Advance Access originally published online on February 18, 2009
Nephrology Dialysis Transplantation 2009 24(5):1682-1685; doi:10.1093/ndt/gfp044
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Immunoprotection by polyethylene glycol in organ preservation solutions is not due to an immunomasking effect

Hélène Perrin1, Olivier Thaunat1,2, Christophe Malcus3, Lionel Badet4, Ana Hennino1, Ricardo Codas4, Françoise Touraine-Moulin3, Jean-François Nicolas1 and Emmanuel Morelon1,2

1 INSERM, U851, 21 Avenue Tony Garnier, Lyon, F-69007, France, Université Lyon 1, Villeurbanne, F-69622, France, IFR128, Lyon, F-69007 2 Service de Néphrologie et Transplantation 3 Laboratoire d’Immunologie 4 Service d’Urologie et chirurgie de la Transplantation, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, F-69003, France

Correspondence and offprint requests to: Hélène Perrin, INSERM, U851, 21 Avenue Tony Garnier, Lyon, F-69007, France. Tel: +33-4-37-28-23-43; Fax: +33-4-37-28-23-41; E-mail: helene.perrin{at}inserm.fr



  Abstract

Background: New organ preservation solutions that contain soluble polyethylene glycol (sPEG) molecules have been associated with reduction of acute rejection episodes.

Methods: In the present manuscript we tested in vitro whether sPEG molecules were able to mask donor alloantigens and reduce graft immunogenicity.

Results: Immunomasking effect was only evidenced when PEG molecules were covalently bound to donor cell surface.

Conclusion: We concluded that sPEG in preservation solution are unlikely to display ‘immunocamoflage’ property.

Keywords: immunocamouflage; ischemia/reperfusion; organ preservation solution; polyethylene glycols; transplantation

Received for publication: 25. 8.08
Accepted in revised form: 22. 1.09


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