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NDT Advance Access originally published online on January 22, 2009
Nephrology Dialysis Transplantation 2009 24(4):1345-1349; doi:10.1093/ndt/gfn749
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Silent recovery of native kidney function after transplantation in a patient with membranous nephropathy

Bernard Descœudres1, Olivier Giannini2, Markus Aschwanden3, Thomas Eugster4, Helmut Hopfer5, Michael J. Mihatsch5, Juerg Steiger1 and Michael Mayr1

1 Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel 2 Nephrology and Internal Medicine Services, Ospedale Regionale Beata Vergine, Mendrisio 3 Clinic for Angiology, University Hospital Basel 4 University Vascular Center Aarau/Basel, University Hospital Basel 5 Institute for Pathology, University Hospital Basel, Basel, Switzerland

Correspondence and offprint requests to: Michael Mayr, Clinic for Transplantation Immunology and Nephrology, University Hospital, Petersgraben 4, 4031 Basel, Switzerland. Tel: +41-61-265-25-25; Fax: +41-61-265-24-10; E-mail: mmayr{at}uhbs.ch



  Abstract

Recurrence of membranous nephropathy (MN) is frequently seen after transplantation. However, there are no published data about the course of MN in the native kidneys after transplantation. Disease progression in almost all cases is assumed to be the ‘natural’ course after transplantation. We report on a patient suffering from end-stage renal disease due to MN. Eight years after transplantation, nephrectomy was performed due to chronic rejection and unexpectedly, partial recovery of native kidney function was noted. As far as we know, there is no other similar case reported in the literature. The potential impact of the immunosuppression, especially of calcineurin inhibitors, is discussed.

Keywords: calcineurin inhibitors; kidney transplantation; membranous nephropathy; recovery of renal function

Received for publication: 7.10.08
Accepted in revised form: 12.12.08


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