Skip Navigation


NDT Advance Access originally published online on November 5, 2008
Nephrology Dialysis Transplantation 2009 24(4):1226-1232; doi:10.1093/ndt/gfn615
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
24/4/1226    most recent
gfn615v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kim, S.-j.
Right arrow Articles by Hong, S.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, S.-j.
Right arrow Articles by Hong, S.-Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


The clinical features of acute kidney injury in patients with acute paraquat intoxication

Su-ji Kim, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee and Sae-Yong Hong

Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea

Correspondence and offprint requests to: Hyo-Wook Gil, Department of Internal Medicine, Soonchunhyang Cheonan Hospital, 23-20 Bongmyung-Dong, Cheonan, Chungnam 330-100, Korea. Tel: +82-41-570-3671; Fax: +82-41-574-5762; E-mail: hwgil{at}schch.co.kr



  Abstract

Background. Paraquat (PQ) is a non-selective herbicide that generates reactive oxygen species in vivo. We hypothesized that acute kidney injury (AKI) in patients with acute PQ poisoning would provide a model for the clinical features of ROS-induced AKI.

Methods. From January 2007 to December 2007, 278 patients with acute PQ intoxication were included in the study. AKI was defined based on the RIFLE classification. The serial changes of creatinine (Cr), the incidence of AKI and the mortality according to the RIFLE classification were analysed.

Results. An initial serum Cr >1.2 mg/dL was a significant predictor of mortality [odds ratio 9.00, 95% C.I. (4.747, 17.061), P < 0.01]. The incidence of AKI was 51.4% among the 173 patients who had an initial serum Cr ≤1.2 mg/dL. Among them, 34.7% were the failure group and oliguric AKI was observed in 10 patients. The average peak serum Cr level, among the 13 survivors in the failure group, was 4.38 mg/dL at the fifth day, after ingestion, and their Cr level normalized within 3 weeks. None of the 13 survivors had permanent loss of renal function. The estimated amount of PQ ingestion was a predictor of the incidence of AKI. The mortality risk was significantly higher in the failure group than in the group without failure.

Conclusion. The clinical feature was characterized by fully developed AKI at the fifth day after PQ ingestion and normalized within 3 weeks without exception.

Keywords: Acute renal failure; paraquat; reactive oxygen species

Received for publication: 14. 7.08
Accepted in revised form: 9.10.08


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.